Mutation of the Fiber Shaft Heparan Sulphate Binding Site of a 5/3 Chimeric Adenovirus Reduces Liver Tropism

Natural tropism to the liver is a major obstacle in systemic delivery of adenoviruses in cancer gene therapy. Adenovirus binding to soluble coagulation factors and to cellular heparan sulphate proteoglycans via the fiber shaft KKTK domain are suggested to cause liver tropism. Serotype 5 adenovirus c...

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Detalles Bibliográficos
Autores principales: Koski, Anniina, Karli, Eerika, Kipar, Anja, Escutenaire, Sophie, Kanerva, Anna, Hemminki, Akseli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621953/
https://www.ncbi.nlm.nih.gov/pubmed/23585829
http://dx.doi.org/10.1371/journal.pone.0060032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621953/
https://www.ncbi.nlm.nih.gov/pubmed/23585829
http://dx.doi.org/10.1371/journal.pone.0060032

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