Efficient and specific gene knockdown by small interfering RNAs produced in bacteria

Synthetic small interfering RNAs (siRNAs) are an indispensable tool to investigate gene function in eukaryotic cells(1,2) and may be used for therapeutic purposes to knockdown genes implicated in disease(3). Thus far, most synthetic siRNAs have been produced by chemical synthesis. Here we present a...

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Detalles Bibliográficos
Autores principales: Huang, Linfeng, Jin, Jingmin, Deighan, Padraig, Kiner, Evgeny, McReynolds, Larry, Lieberman, Judy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622153/
https://www.ncbi.nlm.nih.gov/pubmed/23475073
http://dx.doi.org/10.1038/nbt.2537

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622153/
https://www.ncbi.nlm.nih.gov/pubmed/23475073
http://dx.doi.org/10.1038/nbt.2537

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