Activation of AMP-Activated Protein Kinase α and Extracelluar Signal-Regulated Kinase Mediates CB-PIC-Induced Apoptosis in Hypoxic SW620 Colorectal Cancer Cells

Here, antitumor mechanism of cinnamaldehyde derivative CB-PIC was elucidated in human SW620 colon cancer cells. CB-PIC significantly exerted cytotoxicity, increased sub-G1 accumulation, and cleaved PARP with apoptotic features, while it enhanced the phosphorylation of AMPK alpha and ACC as well as a...

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Detalles Bibliográficos
Autores principales: Cho, Sung-Yun, Lee, Hyo-Jeong, Lee, Hyo-Jung, Jung, Deok-Beom, Kim, Hyunseok, Sohn, Eun Jung, Kim, Bonglee, Jung, Ji Hoon, Kwon, Byoung-Mog, Kim, Sung-Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622407/
https://www.ncbi.nlm.nih.gov/pubmed/23589723
http://dx.doi.org/10.1155/2013/974313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622407/
https://www.ncbi.nlm.nih.gov/pubmed/23589723
http://dx.doi.org/10.1155/2013/974313

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