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Efficient production of chimeric mice from embryonic stem cells injected into 4- to 8-cell and blastocyst embryos
BACKGROUND: Production of chimeric mice is a useful tool for the elucidation of gene function. After successful isolation of embryonic stem (ES) cell lines, there are many methods for producing chimeras, including co-culture with the embryos, microinjection of the ES cells into pre-implantation embr...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622560/ https://www.ncbi.nlm.nih.gov/pubmed/23514327 http://dx.doi.org/10.1186/2049-1891-4-12 |