Screening Compounds with a Novel High-Throughput ABCB1-Mediated Efflux Assay Identifies Drugs with Known Therapeutic Targets at Risk for Multidrug Resistance Interference

ABCB1, also known as P-glycoprotein (P-gp) or multidrug resistance protein 1 (MDR1), is a membrane-associated multidrug transporter of the ATP-binding cassette (ABC) transporter family. It is one of the most widely studied transporters that enable cancer cells to develop drug resistance. Reliable hi...

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Detalles Bibliográficos
Autores principales: Ansbro, Megan R., Shukla, Suneet, Ambudkar, Suresh V., Yuspa, Stuart H., Li, Luowei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622673/
https://www.ncbi.nlm.nih.gov/pubmed/23593196
http://dx.doi.org/10.1371/journal.pone.0060334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622673/
https://www.ncbi.nlm.nih.gov/pubmed/23593196
http://dx.doi.org/10.1371/journal.pone.0060334

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