Attenuation of Nonsense-Mediated mRNA Decay Enhances In Vivo Nonsense Suppression

Nonsense suppression therapy is an approach to treat genetic diseases caused by nonsense mutations. This therapeutic strategy pharmacologically suppresses translation termination at Premature Termination Codons (PTCs) in order to restore expression of functional protein. However, the process of Nons...

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Detalles Bibliográficos
Autores principales: Keeling, Kim M., Wang, Dan, Dai, Yanying, Murugesan, Srinivasan, Chenna, Balachandra, Clark, Jeremy, Belakhov, Valery, Kandasamy, Jeyakumar, Velu, Sadanandan E., Baasov, Timor, Bedwell, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622682/
https://www.ncbi.nlm.nih.gov/pubmed/23593225
http://dx.doi.org/10.1371/journal.pone.0060478

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622682/
https://www.ncbi.nlm.nih.gov/pubmed/23593225
http://dx.doi.org/10.1371/journal.pone.0060478

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