NADPH oxidase inhibition prevents beta cell dysfunction induced by prolonged elevation of oleate in rodents

AIMS/HYPOTHESIS: The activation of NADPH oxidase has been implicated in NEFA-induced beta cell dysfunction. However, the causal role of this activation in vivo remains unclear. Here, using rodents, we investigated whether pharmacological or genetic inhibition of NADPH oxidase could prevent NEFA-indu...

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Detalles Bibliográficos
Autores principales: Koulajian, K., Desai, T., Liu, G. C., Ivovic, A., Patterson, J. N., Tang, C., El-Benna, J., Joseph, J. W., Scholey, J. W., Giacca, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622749/
https://www.ncbi.nlm.nih.gov/pubmed/23429921
http://dx.doi.org/10.1007/s00125-013-2858-4

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