Radiosynthesis and preclinical evaluation of [(11)C]prucalopride as a potential agonist PET ligand for the 5-HT(4) receptor

BACKGROUND: Serotonin 5-HT(4) receptor (5-HT(4)-R) agonists are potential therapeutic agents for enterokinetic and cognitive disorders and are marketed for treatment of constipation. The aim of this study was to develop an agonist positron emission tomography (PET) ligand in order to label the activ...

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Detalles Bibliográficos
Autores principales: Buiter, Hans JC, Windhorst, Albert D, Huisman, Marc C, De Maeyer, Joris H, Schuurkes, Jan AJ, Lammertsma, Adriaan A, Leysen, Josée E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623622/
https://www.ncbi.nlm.nih.gov/pubmed/23557209
http://dx.doi.org/10.1186/2191-219X-3-24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623622/
https://www.ncbi.nlm.nih.gov/pubmed/23557209
http://dx.doi.org/10.1186/2191-219X-3-24

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