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Lynch syndrome related endometrial cancer: clinical significance beyond the endometrium

Lynch syndrome (LS), an autosomal dominant inherited cancer susceptibility syndrome, also known as hereditary non-polyposis colon cancer (HNPCC), is caused by a germline mutation in one of several DNA mismatch repair (MMR) genes. LS is the most common presentation of hereditary colorectal cancer (CR...

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Detalles Bibliográficos
Autores principales: Wang, Yiying, Wang, Yue, Li, Jie, Cragun, Janiel, Hatch, Kenneth, Chambers, Setsuko K, Zheng, Wenxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623651/
https://www.ncbi.nlm.nih.gov/pubmed/23531335
http://dx.doi.org/10.1186/1756-8722-6-22
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author Wang, Yiying
Wang, Yue
Li, Jie
Cragun, Janiel
Hatch, Kenneth
Chambers, Setsuko K
Zheng, Wenxin
author_facet Wang, Yiying
Wang, Yue
Li, Jie
Cragun, Janiel
Hatch, Kenneth
Chambers, Setsuko K
Zheng, Wenxin
author_sort Wang, Yiying
collection PubMed
description Lynch syndrome (LS), an autosomal dominant inherited cancer susceptibility syndrome, also known as hereditary non-polyposis colon cancer (HNPCC), is caused by a germline mutation in one of several DNA mismatch repair (MMR) genes. LS is the most common presentation of hereditary colorectal cancer (CRC), accounting for about 2–5% of all CRC cases. More recently, it is found that a similar number of endometrial cancers is also due to one of the MMR gene mutations. There has been significant progress in LS-related CRC in terms of molecular pathogenesis, risks, genetic basis, and cancer prevention. In contrast, the advance about LS-related endometrial cancer (EC) is very much limited. In this commentary, we summarize the main clinicopathologic features of LS-related EC and propose universal screening for LS in individuals with endometrial cancer.
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spelling pubmed-36236512013-04-12 Lynch syndrome related endometrial cancer: clinical significance beyond the endometrium Wang, Yiying Wang, Yue Li, Jie Cragun, Janiel Hatch, Kenneth Chambers, Setsuko K Zheng, Wenxin J Hematol Oncol Commentary Lynch syndrome (LS), an autosomal dominant inherited cancer susceptibility syndrome, also known as hereditary non-polyposis colon cancer (HNPCC), is caused by a germline mutation in one of several DNA mismatch repair (MMR) genes. LS is the most common presentation of hereditary colorectal cancer (CRC), accounting for about 2–5% of all CRC cases. More recently, it is found that a similar number of endometrial cancers is also due to one of the MMR gene mutations. There has been significant progress in LS-related CRC in terms of molecular pathogenesis, risks, genetic basis, and cancer prevention. In contrast, the advance about LS-related endometrial cancer (EC) is very much limited. In this commentary, we summarize the main clinicopathologic features of LS-related EC and propose universal screening for LS in individuals with endometrial cancer. BioMed Central 2013-03-25 /pmc/articles/PMC3623651/ /pubmed/23531335 http://dx.doi.org/10.1186/1756-8722-6-22 Text en Copyright © 2013 Wang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Wang, Yiying
Wang, Yue
Li, Jie
Cragun, Janiel
Hatch, Kenneth
Chambers, Setsuko K
Zheng, Wenxin
Lynch syndrome related endometrial cancer: clinical significance beyond the endometrium
title Lynch syndrome related endometrial cancer: clinical significance beyond the endometrium
title_full Lynch syndrome related endometrial cancer: clinical significance beyond the endometrium
title_fullStr Lynch syndrome related endometrial cancer: clinical significance beyond the endometrium
title_full_unstemmed Lynch syndrome related endometrial cancer: clinical significance beyond the endometrium
title_short Lynch syndrome related endometrial cancer: clinical significance beyond the endometrium
title_sort lynch syndrome related endometrial cancer: clinical significance beyond the endometrium
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623651/
https://www.ncbi.nlm.nih.gov/pubmed/23531335
http://dx.doi.org/10.1186/1756-8722-6-22
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