Proteolytically Inactive Insulin-Degrading Enzyme Inhibits Amyloid Formation Yielding Non-Neurotoxic Aβ Peptide Aggregates

Insulin-degrading enzyme (IDE) is a neutral Zn(2+) peptidase that degrades short peptides based on substrate conformation, size and charge. Some of these substrates, including amyloid β (Aβ) are capable of self-assembling into cytotoxic oligomers. Based on IDE recognition mechanism and our previous...

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Detalles Bibliográficos
Autores principales: de Tullio, Matias B., Castelletto, Valeria, Hamley, Ian W., Martino Adami, Pamela V., Morelli, Laura, Castaño, Eduardo M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623905/
https://www.ncbi.nlm.nih.gov/pubmed/23593132
http://dx.doi.org/10.1371/journal.pone.0059113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623905/
https://www.ncbi.nlm.nih.gov/pubmed/23593132
http://dx.doi.org/10.1371/journal.pone.0059113

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