Tetramerization of SAMHD1 Is Required for Biological Activity and Inhibition of HIV Infection

SAMHD1 is a dGTP-activated dNTPase that has been implicated as a modulator of the innate immune response. In monocytes and their differentiated derivatives, as well as in quiescent cells, SAMHD1 strongly inhibits HIV-1 infection and, to a lesser extent, HIV-2 and simian immunodeficiency virus (SIV)...

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Detalles Bibliográficos
Autores principales: Yan, Junpeng, Kaur, Sarabpreet, DeLucia, Maria, Hao, Caili, Mehrens, Jennifer, Wang, Chuanping, Golczak, Marcin, Palczewski, Krzysztof, Gronenborn, Angela M., Ahn, Jinwoo, Skowronski, Jacek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624423/
https://www.ncbi.nlm.nih.gov/pubmed/23426366
http://dx.doi.org/10.1074/jbc.M112.443796

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624423/
https://www.ncbi.nlm.nih.gov/pubmed/23426366
http://dx.doi.org/10.1074/jbc.M112.443796

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