γ-H2AX + CD8+ T lymphocytes cannot respond to IFN-α, IL-2 or IL-6 in chronic hepatitis C virus infection

BACKGROUND & AIMS: Age is the dominant prognostic factor influencing the natural history of hepatitis C virus (HCV) infection and treatment response. Accelerated lymphocyte telomere shortening in HCV infection correlates with adverse clinical outcomes. Critical telomere shortening generates doub...

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Detalles Bibliográficos
Autores principales: Hoare, Matthew, Shankar, Arun, Shah, Meera, Rushbrook, Simon, Gelson, William, Davies, Susan, Akbar, Arne, Alexander, Graeme J.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625113/
https://www.ncbi.nlm.nih.gov/pubmed/23257612
http://dx.doi.org/10.1016/j.jhep.2012.12.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625113/
https://www.ncbi.nlm.nih.gov/pubmed/23257612
http://dx.doi.org/10.1016/j.jhep.2012.12.009

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