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γ-H2AX + CD8+ T lymphocytes cannot respond to IFN-α, IL-2 or IL-6 in chronic hepatitis C virus infection

BACKGROUND & AIMS: Age is the dominant prognostic factor influencing the natural history of hepatitis C virus (HCV) infection and treatment response. Accelerated lymphocyte telomere shortening in HCV infection correlates with adverse clinical outcomes. Critical telomere shortening generates doub...

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Detalles Bibliográficos
Autores principales:	Hoare, Matthew, Shankar, Arun, Shah, Meera, Rushbrook, Simon, Gelson, William, Davies, Susan, Akbar, Arne, Alexander, Graeme J.M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625113/ https://www.ncbi.nlm.nih.gov/pubmed/23257612 http://dx.doi.org/10.1016/j.jhep.2012.12.009

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