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Understanding the Folding-Function Tradeoff in Proteins

When an amino-acid sequence cannot be optimized for both folding and function, folding can get compromised in favor of function. To understand this tradeoff better, we devise a novel method for extracting the “function-less” folding-motif of a protein fold from a set of structurally similar but func...

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Detalles Bibliográficos
Autor principal: Gosavi, Shachi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625163/
https://www.ncbi.nlm.nih.gov/pubmed/23593437
http://dx.doi.org/10.1371/journal.pone.0061222