Rapid Screening of Drug-Protein Binding Using High-Performance Affinity Chromatography with Columns Containing Immobilized Human Serum Albumin

For drug candidates, a plasma protein binding (PPB) more than 90% is more meaningful and deserves further investigation in development. In the study, a high-performance liquid chromatography method employing column containing immobilized human serum albumin (HSA) to screen in vitro PPB of leading co...

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Detalles Bibliográficos
Autores principales: Li, Ying-Fei, Zhang, Xiao-Qiong, Hu, Wei-Yu, Li, Zheng, Liu, Ping-Xia, Zhang, Zhen-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625562/
https://www.ncbi.nlm.nih.gov/pubmed/23607050
http://dx.doi.org/10.1155/2013/439039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625562/
https://www.ncbi.nlm.nih.gov/pubmed/23607050
http://dx.doi.org/10.1155/2013/439039

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