Cargando…

PPARδ Agonist GW501516 Inhibits PDGF-Stimulated Pulmonary Arterial Smooth Muscle Cell Function Related to Pathological Vascular Remodeling

Pulmonary arterial hypertension (PAH) is a severe and progressive disease, a key feature of which is pulmonary vascular remodeling. Growth factors, cytokines, and lipid mediators are involved in this remodeling process. Recent reports suggest that the peroxisome proliferator-activated receptors (PPA...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Guangjie, Li, Xuan, Li, Yan, Tang, Xin, Xu, Jie, Li, Ran, Hao, Peng, Sun, Yongchang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625582/ https://www.ncbi.nlm.nih.gov/pubmed/23607100 http://dx.doi.org/10.1155/2013/903947

Ejemplares similares

A metabolomic study of the PPARδ agonist GW501516 for enhancing running endurance in Kunming mice
por: Chen, Wei, et al.
Publicado: (2015)

The Role of PPARδ Agosnist GW501516 in Rats with Gestational Diabetes Mellitus
por: Zhou, Jun, et al.
Publicado: (2020)

PPARβ/δ Agonist GW501516 Inhibits Tumorigenicity of Undifferentiated Nasopharyngeal Carcinoma in C666-1 Cells by Promoting Apoptosis
por: Ji, Yangyang, et al.
Publicado: (2018)

PPARδ Agonist GW501516 Suppresses the TGF-β-Induced Profibrotic Response of Human Bronchial Fibroblasts from Asthmatic Patients
por: Paw, Milena, et al.
Publicado: (2023)

Effects of the PPAR-β agonist GW501516 in an in vitro model of brain inflammation and antibody-induced demyelination
por: Defaux, Antoinette, et al.
Publicado: (2009)

The PPARδ Ligand GW501516 Reduces Growth but Not Apoptosis in Mouse Inner Medullary Collecting Duct Cells
por: Clark, Jordan, et al.
Publicado: (2009)

The PPARδ Agonist GW501516 Improves Lipolytic/Lipogenic Balance through CPT1 and PEPCK during the Development of Pre-Implantation Bovine Embryos
por: Idrees, Muhammad, et al.
Publicado: (2019)

GW501516, a PPAR-BETA/DELTA agonist, improves inflammatory pathways in the kidney of high-fructose fed mice
por: Magliano, D'Angelo Carlo, et al.
Publicado: (2015)

GW501516, a PPARδ Agonist, Ameliorates Tubulointerstitial Inflammation in Proteinuric Kidney Disease via Inhibition of TAK1-NFκB Pathway in Mice
por: Yang, Xu, et al.
Publicado: (2011)

PPARβ/δ Agonist GW501516 Inhibits Tumorigenesis and Promotes Apoptosis of the Undifferentiated Nasopharyngeal Carcinoma C666-1 Cells by Regulating miR-206
por: Gu, Linglan, et al.
Publicado: (2019)

GW501516-activated PPARβ/δ promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation
por: Kostadinova, Radina, et al.
Publicado: (2012)

PPARβ/δ Agonism with GW501516 Increases Myotube PGC-1α Content and Reduces BCAA Media Content Independent of Changes in BCAA Catabolic Enzyme Expression
por: Rivera, Caroline N., et al.
Publicado: (2023)

Effects of the PPAR-β/δ agonist GW0742 during resuscitated porcine septic shock
por: Wepler, Martin, et al.
Publicado: (2013)

Therapeutic potential of GW501516 and the role of Peroxisome proliferator-activated receptor β/δ and B-cell lymphoma 6 in inflammatory signaling in human pancreatic cancer cells
por: Smith, Russell W., et al.
Publicado: (2016)

Development of PPAR-agonist GW0742 as antidiabetic drug: study in animals
por: Niu, Ho-Shan, et al.
Publicado: (2015)

Context-dependent regulation of endothelial cell metabolism: differential effects of the PPARβ/δ agonist GW0742 and VEGF-A
por: Faulkner, Ashton, et al.
Publicado: (2020)

Molecular and nanoscale evaluation of N-cadherin expression in invasive bladder cancer cells under control conditions or GW501516 exposure
por: Elie-Caille, Céline, et al.
Publicado: (2020)

PPAR-γ Agonist GW1929 But Not Antagonist GW9662 Reduces TBBPA-Induced Neurotoxicity in Primary Neocortical Cells
por: Wojtowicz, Anna K., et al.
Publicado: (2013)

Investigating the Role of PPARβ/δ in Retinal Vascular Remodeling Using Pparβ/δ-Deficient Mice
por: Ho, Sze Yuan, et al.
Publicado: (2020)

PPARβ/δ, a Novel Regulator for Vascular Smooth Muscle Cells Phenotypic Modulation and Vascular Remodeling after Subarachnoid Hemorrhage in Rats
por: Zhang, Hongrong, et al.
Publicado: (2017)

The PPARβ/δAgonist GW0742 Relaxes Pulmonary Vessels and Limits Right Heart Hypertrophy in Rats with Hypoxia-Induced Pulmonary Hypertension
por: Harrington, Louise S., et al.
Publicado: (2010)

Apatinib attenuates phenotypic switching of arterial smooth muscle cells in vascular remodelling by targeting the PDGF Receptor‐β
por: Shao, Wenchao, et al.
Publicado: (2020)

Structure-Based Virtual Screening and Discovery of New PPARδ/γ Dual Agonist and PPARδ and γ Agonists
por: Maltarollo, Vinicius G., et al.
Publicado: (2015)

Evodiamine Attenuates PDGF-BB-Induced Migration of Rat Vascular Smooth Muscle Cells through Activating PPARγ
por: Ge, Xie, et al.
Publicado: (2015)

PPAR-δ in Vascular Pathophysiology
por: Wang, Nanping
Publicado: (2008)

PPAR-γ Agonist GW1929 Targeted to Macrophages with Dendrimer–Graphene Nanostars Reduces Liver Fibrosis and Inflammation
por: Moreno-Lanceta, Alazne, et al.
Publicado: (2023)

VCAM-1-targeted and PPARδ-agonist-loaded nanomicelles enhanced suppressing effects on apoptosis and migration of oxidized low-density lipoprotein-induced vascular smooth muscle cells
por: Wei, Gang, et al.
Publicado: (2020)

Endogenous hydrogen sulfide improves vascular remodeling through PPARδ/SOCS3 signaling
por: Tian, Danyang, et al.
Publicado: (2020)

Reduced expression of PPAR-β/δ limits the potential beneficial effects of GW0742 during septic shock in atherosclerotic swine
por: Bracht, H, et al.
Publicado: (2012)

Importance of the Proximity and Orientation of Ligand-Linkage to the Design of Cinnamate-GW9662 Hybrid Compounds as Covalent PPARγ Agonists
por: Utsugi, Yuki, et al.
Publicado: (2019)

c-Ski Inhibits Autophagy of Vascular Smooth Muscle Cells Induced by oxLDL and PDGF
por: Li, Jun, et al.
Publicado: (2014)

ICAM-1-Targeted Liposomes Loaded with Liver X Receptor Agonists Suppress PDGF-Induced Proliferation of Vascular Smooth Muscle Cells
por: Huang, Xu, et al.
Publicado: (2017)

PPARα-Independent Arterial Smooth Muscle Relaxant Effects of PPARα Agonists
por: Silswal, Neerupma, et al.
Publicado: (2012)

Inhibition of Doxorubicin-Induced Senescence by PPARδ Activation Agonists in Cardiac Muscle Cells: Cooperation between PPARδ and Bcl6
por: Altieri, Paola, et al.
Publicado: (2012)

Differential Expression and Bioinformatics Analysis of CircRNA in PDGF-BB-Induced Vascular Smooth Muscle Cells
por: Tian, Jiangtian, et al.
Publicado: (2020)

Ligand-activated PPARδ inhibits angiotensin II-stimulated hypertrophy of vascular smooth muscle cells by targeting ROS
por: Kang, Eun Sil, et al.
Publicado: (2019)

PDGF regulates guanylate cyclase expression and cGMP signaling in vascular smooth muscle
por: Hildebrand, Staffan, et al.
Publicado: (2022)

Enhanced Rb/E2F and TSC/mTOR Pathways Induce Synergistic Inhibition in PDGF-Induced Proliferation in Vascular Smooth Muscle Cells
por: Li, Yue, et al.
Publicado: (2017)

Vascular PPARβ/δ Promotes Tumor Angiogenesis and Progression
por: Wagner, Kay-Dietrich, et al.
Publicado: (2019)

Mechanical strain induces growth of vascular smooth muscle cells via autocrine action of PDGF
Publicado: (1993)

Cannot write session to /tmp/vufind_sessions/sess_509ch5if33r0lumkcbfe8lo038