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The sequence and analysis of a Chinese pig genome

BACKGROUND: The pig is an economically important food source, amounting to approximately 40% of all meat consumed worldwide. Pigs also serve as an important model organism because of their similarity to humans at the anatomical, physiological and genetic level, making them very useful for studying a...

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Autores principales: Fang, Xiaodong, Mou, Yulian, Huang, Zhiyong, Li, Yong, Han, Lijuan, Zhang, Yanfeng, Feng, Yue, Chen, Yuanxin, Jiang, Xuanting, Zhao, Wei, Sun, Xiaoqing, Xiong, Zhiqiang, Yang, Lan, Liu, Huan, Fan, Dingding, Mao, Likai, Ren, Lijie, Liu, Chuxin, Wang, Juan, Li, Kui, Wang, Guangbiao, Yang, Shulin, Lai, Liangxue, Zhang, Guojie, Li, Yingrui, Wang, Jun, Bolund, Lars, Yang, Huanming, Wang, Jian, Feng, Shutang, Li, Songgang, Du, Yutao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626506/
https://www.ncbi.nlm.nih.gov/pubmed/23587058
http://dx.doi.org/10.1186/2047-217X-1-16
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author Fang, Xiaodong
Mou, Yulian
Huang, Zhiyong
Li, Yong
Han, Lijuan
Zhang, Yanfeng
Feng, Yue
Chen, Yuanxin
Jiang, Xuanting
Zhao, Wei
Sun, Xiaoqing
Xiong, Zhiqiang
Yang, Lan
Liu, Huan
Fan, Dingding
Mao, Likai
Ren, Lijie
Liu, Chuxin
Wang, Juan
Li, Kui
Wang, Guangbiao
Yang, Shulin
Lai, Liangxue
Zhang, Guojie
Li, Yingrui
Wang, Jun
Bolund, Lars
Yang, Huanming
Wang, Jian
Feng, Shutang
Li, Songgang
Du, Yutao
author_facet Fang, Xiaodong
Mou, Yulian
Huang, Zhiyong
Li, Yong
Han, Lijuan
Zhang, Yanfeng
Feng, Yue
Chen, Yuanxin
Jiang, Xuanting
Zhao, Wei
Sun, Xiaoqing
Xiong, Zhiqiang
Yang, Lan
Liu, Huan
Fan, Dingding
Mao, Likai
Ren, Lijie
Liu, Chuxin
Wang, Juan
Li, Kui
Wang, Guangbiao
Yang, Shulin
Lai, Liangxue
Zhang, Guojie
Li, Yingrui
Wang, Jun
Bolund, Lars
Yang, Huanming
Wang, Jian
Feng, Shutang
Li, Songgang
Du, Yutao
author_sort Fang, Xiaodong
collection PubMed
description BACKGROUND: The pig is an economically important food source, amounting to approximately 40% of all meat consumed worldwide. Pigs also serve as an important model organism because of their similarity to humans at the anatomical, physiological and genetic level, making them very useful for studying a variety of human diseases. A pig strain of particular interest is the miniature pig, specifically the Wuzhishan pig (WZSP), as it has been extensively inbred. Its high level of homozygosity offers increased ease for selective breeding for specific traits and a more straightforward understanding of the genetic changes that underlie its biological characteristics. WZSP also serves as a promising means for applications in surgery, tissue engineering, and xenotransplantation. Here, we report the sequencing and analysis of an inbreeding WZSP genome. RESULTS: Our results reveal some unique genomic features, including a relatively high level of homozygosity in the diploid genome, an unusual distribution of heterozygosity, an over-representation of tRNA-derived transposable elements, a small amount of porcine endogenous retrovirus, and a lack of type C retroviruses. In addition, we carried out systematic research on gene evolution, together with a detailed investigation of the counterparts of human drug target genes. CONCLUSION: Our results provide the opportunity to more clearly define the genomic character of pig, which could enhance our ability to create more useful pig models.
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spelling pubmed-36265062013-04-24 The sequence and analysis of a Chinese pig genome Fang, Xiaodong Mou, Yulian Huang, Zhiyong Li, Yong Han, Lijuan Zhang, Yanfeng Feng, Yue Chen, Yuanxin Jiang, Xuanting Zhao, Wei Sun, Xiaoqing Xiong, Zhiqiang Yang, Lan Liu, Huan Fan, Dingding Mao, Likai Ren, Lijie Liu, Chuxin Wang, Juan Li, Kui Wang, Guangbiao Yang, Shulin Lai, Liangxue Zhang, Guojie Li, Yingrui Wang, Jun Bolund, Lars Yang, Huanming Wang, Jian Feng, Shutang Li, Songgang Du, Yutao Gigascience Research BACKGROUND: The pig is an economically important food source, amounting to approximately 40% of all meat consumed worldwide. Pigs also serve as an important model organism because of their similarity to humans at the anatomical, physiological and genetic level, making them very useful for studying a variety of human diseases. A pig strain of particular interest is the miniature pig, specifically the Wuzhishan pig (WZSP), as it has been extensively inbred. Its high level of homozygosity offers increased ease for selective breeding for specific traits and a more straightforward understanding of the genetic changes that underlie its biological characteristics. WZSP also serves as a promising means for applications in surgery, tissue engineering, and xenotransplantation. Here, we report the sequencing and analysis of an inbreeding WZSP genome. RESULTS: Our results reveal some unique genomic features, including a relatively high level of homozygosity in the diploid genome, an unusual distribution of heterozygosity, an over-representation of tRNA-derived transposable elements, a small amount of porcine endogenous retrovirus, and a lack of type C retroviruses. In addition, we carried out systematic research on gene evolution, together with a detailed investigation of the counterparts of human drug target genes. CONCLUSION: Our results provide the opportunity to more clearly define the genomic character of pig, which could enhance our ability to create more useful pig models. BioMed Central 2012-11-15 /pmc/articles/PMC3626506/ /pubmed/23587058 http://dx.doi.org/10.1186/2047-217X-1-16 Text en Copyright © 2012 Fang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Fang, Xiaodong
Mou, Yulian
Huang, Zhiyong
Li, Yong
Han, Lijuan
Zhang, Yanfeng
Feng, Yue
Chen, Yuanxin
Jiang, Xuanting
Zhao, Wei
Sun, Xiaoqing
Xiong, Zhiqiang
Yang, Lan
Liu, Huan
Fan, Dingding
Mao, Likai
Ren, Lijie
Liu, Chuxin
Wang, Juan
Li, Kui
Wang, Guangbiao
Yang, Shulin
Lai, Liangxue
Zhang, Guojie
Li, Yingrui
Wang, Jun
Bolund, Lars
Yang, Huanming
Wang, Jian
Feng, Shutang
Li, Songgang
Du, Yutao
The sequence and analysis of a Chinese pig genome
title The sequence and analysis of a Chinese pig genome
title_full The sequence and analysis of a Chinese pig genome
title_fullStr The sequence and analysis of a Chinese pig genome
title_full_unstemmed The sequence and analysis of a Chinese pig genome
title_short The sequence and analysis of a Chinese pig genome
title_sort sequence and analysis of a chinese pig genome
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626506/
https://www.ncbi.nlm.nih.gov/pubmed/23587058
http://dx.doi.org/10.1186/2047-217X-1-16
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