Calpain Inhibition Reduces Amplitude and Accelerates Decay of the Late Sodium Current in Ventricular Myocytes from Dogs with Chronic Heart Failure

Calpain is an intracellular Ca(2+) -activated protease that is involved in numerous Ca(2+) dependent regulation of protein function in many cell types. This paper tests a hypothesis that calpains are involved in Ca(2+) -dependent increase of the late sodium current (I(NaL)) in failing heart. Chronic...

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Detalles Bibliográficos
Autores principales: Undrovinas, Albertas, Maltsev, Victor A., Sabbah, Hani N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626653/
https://www.ncbi.nlm.nih.gov/pubmed/23596505
http://dx.doi.org/10.1371/journal.pone.0054436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626653/
https://www.ncbi.nlm.nih.gov/pubmed/23596505
http://dx.doi.org/10.1371/journal.pone.0054436

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