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Calpain Inhibition Reduces Amplitude and Accelerates Decay of the Late Sodium Current in Ventricular Myocytes from Dogs with Chronic Heart Failure
Calpain is an intracellular Ca(2+) -activated protease that is involved in numerous Ca(2+) dependent regulation of protein function in many cell types. This paper tests a hypothesis that calpains are involved in Ca(2+) -dependent increase of the late sodium current (I(NaL)) in failing heart. Chronic...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626653/ https://www.ncbi.nlm.nih.gov/pubmed/23596505 http://dx.doi.org/10.1371/journal.pone.0054436 |