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Inverse expression of hyaluronidase 2 and hyaluronan synthases 1–3 is associated with reduced hyaluronan content in malignant cutaneous melanoma

BACKGROUND: Hyaluronan is an extracellular matrix glycosaminoglycan involved in invasion, proliferation and metastasis of various types of carcinomas. In many cancers, aberrant hyaluronan expression implicates disease progression and metastatic potential. Melanoma is an aggressive skin cancer. The r...

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Detalles Bibliográficos
Autores principales: Hanna, Siiskonen, Mari, Poukka, Kristiina, Tyynelä-Korhonen, Reijo, Sironen, Sanna, Pasonen-Seppänen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626669/
https://www.ncbi.nlm.nih.gov/pubmed/23560496
http://dx.doi.org/10.1186/1471-2407-13-181