MEK and the inhibitors: from bench to bedside

Four distinct MAP kinase signaling pathways involving 7 MEK enzymes have been identified. MEK1 and MEK2 are the prototype members of MEK family proteins. Several MEK inhibitors are in clinical trials. Trametinib is being evaluated by FDA for the treatment of metastatic melanoma with BRAF V600 mutati...

Descripción completa

Detalles Bibliográficos
Autores principales: Akinleye, Akintunde, Furqan, Muhammad, Mukhi, Nikhil, Ravella, Pavan, Liu, Delong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626705/
https://www.ncbi.nlm.nih.gov/pubmed/23587417
http://dx.doi.org/10.1186/1756-8722-6-27

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626705/
https://www.ncbi.nlm.nih.gov/pubmed/23587417
http://dx.doi.org/10.1186/1756-8722-6-27

Ejemplares similares