p300 is elevated in systemic sclerosis and its expression is positively regulated by TGF-β: epigenetic feed-forward amplification of fibrosis

Fibrosis, the hallmark of systemic sclerosis (SSc), is characterized by persistent fibroblast activation triggered by transforming growth factor-β (TGF-β). Since the acetyltransferase p300 plays a key role in fibrosis and its availability governs the intensity of fibrotic responses, we investigated...

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Detalles Bibliográficos
Autores principales: Ghosh, Asish K, Bhattacharyya, Swati, Lafyatis, Robert, Farina, Giuseppina, Yu, Jianxiu, Thimmapaya, Bayar, Wei, Jun, Varga, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626729/
https://www.ncbi.nlm.nih.gov/pubmed/23303459
http://dx.doi.org/10.1038/jid.2012.479

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626729/
https://www.ncbi.nlm.nih.gov/pubmed/23303459
http://dx.doi.org/10.1038/jid.2012.479

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