IL-6 Trans-signaling-STAT3 Pathway Mediates ECM and Cellular Proliferation in Fibroblasts from Hypertrophic Scar

The molecular mechanisms behind the pathogenesis of post-burn hypertrophic scar (HS) remain unclear. Here, we investigate the role of interleukin-6 (IL-6) trans-signaling-STAT3 pathway in HS fibroblasts (HSF) derived from burned-induced HS skin. HSF showed increased Tyr 705 STAT3 phosphorylation ove...

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Detalles Bibliográficos
Autores principales: Ray, Sutapa, Ju, Xiaoxi, Sun, Hong, Finnerty, Celeste C, Herndon, David N, Brasier, Allan R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626764/
https://www.ncbi.nlm.nih.gov/pubmed/23303450
http://dx.doi.org/10.1038/jid.2012.499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626764/
https://www.ncbi.nlm.nih.gov/pubmed/23303450
http://dx.doi.org/10.1038/jid.2012.499

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