Drugging Hedgehog: signaling the pathway to translation

First discovered in Drosophila, the Hedgehog signaling pathway controls a wide range of developmental processes and is implicated in a variety of cancers. The success of a screen for chemical modulators of this pathway, published in 2002, opened a new chapter in the quest to translate the results of...

Descripción completa

Detalles Bibliográficos
Autores principales: Carney, Tom J, Ingham, Philip W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626896/
https://www.ncbi.nlm.nih.gov/pubmed/23587183
http://dx.doi.org/10.1186/1741-7007-11-37
_version_ 1782266266322468864
author Carney, Tom J
Ingham, Philip W
author_facet Carney, Tom J
Ingham, Philip W
author_sort Carney, Tom J
collection PubMed
description First discovered in Drosophila, the Hedgehog signaling pathway controls a wide range of developmental processes and is implicated in a variety of cancers. The success of a screen for chemical modulators of this pathway, published in 2002, opened a new chapter in the quest to translate the results of basic developmental biology research into therapeutic applications. Small molecule pathway agonists are now used to program stem cells, whilst antagonists are proving effective as anti-cancer therapies.
format Online
Article
Text
id pubmed-3626896
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-36268962013-04-17 Drugging Hedgehog: signaling the pathway to translation Carney, Tom J Ingham, Philip W BMC Biol Review First discovered in Drosophila, the Hedgehog signaling pathway controls a wide range of developmental processes and is implicated in a variety of cancers. The success of a screen for chemical modulators of this pathway, published in 2002, opened a new chapter in the quest to translate the results of basic developmental biology research into therapeutic applications. Small molecule pathway agonists are now used to program stem cells, whilst antagonists are proving effective as anti-cancer therapies. BioMed Central 2013-04-15 /pmc/articles/PMC3626896/ /pubmed/23587183 http://dx.doi.org/10.1186/1741-7007-11-37 Text en Copyright © 2013 Carney and Ingham; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Carney, Tom J
Ingham, Philip W
Drugging Hedgehog: signaling the pathway to translation
title Drugging Hedgehog: signaling the pathway to translation
title_full Drugging Hedgehog: signaling the pathway to translation
title_fullStr Drugging Hedgehog: signaling the pathway to translation
title_full_unstemmed Drugging Hedgehog: signaling the pathway to translation
title_short Drugging Hedgehog: signaling the pathway to translation
title_sort drugging hedgehog: signaling the pathway to translation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626896/
https://www.ncbi.nlm.nih.gov/pubmed/23587183
http://dx.doi.org/10.1186/1741-7007-11-37
work_keys_str_mv AT carneytomj drugginghedgehogsignalingthepathwaytotranslation
AT inghamphilipw drugginghedgehogsignalingthepathwaytotranslation

Ejemplares similares