Cilia, tubby mice, and obesity

Primary cilia have been previously linked to the central regulation of satiety. The tubby mouse is characterized by maturity-onset obesity and blindness. A recent paper demonstrates molecular defects in trafficking of ciliary GPCRs in the central neurons of tubby mice, underscoring the role of cilia...

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Detalles Bibliográficos
Autores principales: Mukhopadhyay, Saikat, Jackson, Peter K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626941/
https://www.ncbi.nlm.nih.gov/pubmed/23351214
http://dx.doi.org/10.1186/2046-2530-2-1
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author Mukhopadhyay, Saikat
Jackson, Peter K
author_facet Mukhopadhyay, Saikat
Jackson, Peter K
author_sort Mukhopadhyay, Saikat
collection PubMed
description Primary cilia have been previously linked to the central regulation of satiety. The tubby mouse is characterized by maturity-onset obesity and blindness. A recent paper demonstrates molecular defects in trafficking of ciliary GPCRs in the central neurons of tubby mice, underscoring the role of ciliary signaling in the pathogenesis of this monogenic obesity syndrome. Please see related Research article by Li et al., http://www.ciliajournal.com/content/1/1/21
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spelling pubmed-36269412013-04-22 Cilia, tubby mice, and obesity Mukhopadhyay, Saikat Jackson, Peter K Cilia Commentary Primary cilia have been previously linked to the central regulation of satiety. The tubby mouse is characterized by maturity-onset obesity and blindness. A recent paper demonstrates molecular defects in trafficking of ciliary GPCRs in the central neurons of tubby mice, underscoring the role of ciliary signaling in the pathogenesis of this monogenic obesity syndrome. Please see related Research article by Li et al., http://www.ciliajournal.com/content/1/1/21 BioMed Central 2013-01-03 /pmc/articles/PMC3626941/ /pubmed/23351214 http://dx.doi.org/10.1186/2046-2530-2-1 Text en Copyright © 2013 Mukhopadhyay and Jackson; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Mukhopadhyay, Saikat
Jackson, Peter K
Cilia, tubby mice, and obesity
title Cilia, tubby mice, and obesity
title_full Cilia, tubby mice, and obesity
title_fullStr Cilia, tubby mice, and obesity
title_full_unstemmed Cilia, tubby mice, and obesity
title_short Cilia, tubby mice, and obesity
title_sort cilia, tubby mice, and obesity
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626941/
https://www.ncbi.nlm.nih.gov/pubmed/23351214
http://dx.doi.org/10.1186/2046-2530-2-1
work_keys_str_mv AT mukhopadhyaysaikat ciliatubbymiceandobesity
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