p38 (MAPK) stress signalling in replicative senescence in fibroblasts from progeroid and genomic instability syndromes

Werner Syndrome (WS) is a human segmental progeria resulting from mutations in a DNA helicase. WS fibroblasts have a shortened replicative capacity, an aged appearance, and activated p38 MAPK, features that can be modulated by inhibition of the p38 pathway. Loss of the WRNp RecQ helicase has been sh...

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Detalles Bibliográficos
Autores principales: Tivey, Hannah S. E., Brook, Amy J. C., Rokicki, Michal J., Kipling, David, Davis, Terence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627027/
https://www.ncbi.nlm.nih.gov/pubmed/23112078
http://dx.doi.org/10.1007/s10522-012-9407-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627027/
https://www.ncbi.nlm.nih.gov/pubmed/23112078
http://dx.doi.org/10.1007/s10522-012-9407-2

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