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p38 (MAPK) stress signalling in replicative senescence in fibroblasts from progeroid and genomic instability syndromes
Werner Syndrome (WS) is a human segmental progeria resulting from mutations in a DNA helicase. WS fibroblasts have a shortened replicative capacity, an aged appearance, and activated p38 MAPK, features that can be modulated by inhibition of the p38 pathway. Loss of the WRNp RecQ helicase has been sh...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Netherlands
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627027/ https://www.ncbi.nlm.nih.gov/pubmed/23112078 http://dx.doi.org/10.1007/s10522-012-9407-2 |