Methadone but not Morphine Inhibits Lubiprostone-Stimulated Cl(−) Currents in T84 Intestinal Cells and Recombinant Human ClC-2, but not CFTR Cl(−) Currents

In clinical trials, methadone, but not morphine, appeared to prevent beneficial effects of lubiprostone, a ClC-2 Cl(−) channel activator, on opioid-induced constipation. Effects of methadone and morphine on lubiprostone-stimulated Cl(−) currents were measured by short circuit current (Isc) across T8...

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Detalles Bibliográficos
Autores principales: Cuppoletti, John, Chakrabarti, Jayati, Tewari, Kirti, Malinowska, Danuta H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627040/
https://www.ncbi.nlm.nih.gov/pubmed/22918821
http://dx.doi.org/10.1007/s12013-012-9406-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627040/
https://www.ncbi.nlm.nih.gov/pubmed/22918821
http://dx.doi.org/10.1007/s12013-012-9406-6

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