Mechanism of Activation of PKB/Akt by the Protein Phosphatase Inhibitor Calyculin A

The protein phosphatase inhibitor calyculin A activates PKB/Akt to ~50% of the activity induced by insulin-like growth factor 1 (IGF1) in HeLa cells promoting an evident increased phosphorylation of Ser473 despite the apparent lack of Thr308 phosphorylation of PKB. Nevertheless, calyculin A-induced...

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Detalles Bibliográficos
Autores principales: Pozuelo-Rubio, Mercedes, Leslie, Nick R., Murphy, Jane, MacKintosh, Carol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Humana Press Inc 2010
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627045/
https://www.ncbi.nlm.nih.gov/pubmed/20717744
http://dx.doi.org/10.1007/s12013-010-9101-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627045/
https://www.ncbi.nlm.nih.gov/pubmed/20717744
http://dx.doi.org/10.1007/s12013-010-9101-4

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