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Mechanism of Activation of PKB/Akt by the Protein Phosphatase Inhibitor Calyculin A
The protein phosphatase inhibitor calyculin A activates PKB/Akt to ~50% of the activity induced by insulin-like growth factor 1 (IGF1) in HeLa cells promoting an evident increased phosphorylation of Ser473 despite the apparent lack of Thr308 phosphorylation of PKB. Nevertheless, calyculin A-induced...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Humana Press Inc
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627045/ https://www.ncbi.nlm.nih.gov/pubmed/20717744 http://dx.doi.org/10.1007/s12013-010-9101-4 |