Cargando…
Acute sensitivity of the oral mucosa to oncogenic K-ras
Mouse models of cancer represent powerful tools for analysing the role of genetic alterations in carcinogenesis. Using a mouse model that allows tamoxifen-inducible somatic activation (by Cre-mediated recombination) of oncogenic K-ras(G12D) in a wide range of tissues, we observed hyperplasia of squa...
Autores principales: | van der Weyden, Louise, Alcolea, Maria P, Jones, Philip H, Rust, Alistair G, Arends, Mark J, Adams, David J |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd.
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627303/ https://www.ncbi.nlm.nih.gov/pubmed/21381032 http://dx.doi.org/10.1002/path.2853 |
Ejemplares similares
-
Increased tumorigenesis associated with loss of the tumor suppressor gene Cadm1
por: van der Weyden, Louise, et al.
Publicado: (2012) -
The Ras-association domain family (RASSF) members and their role in human tumourigenesis
por: van der Weyden, Louise, et al.
Publicado: (2007) -
Activation of K-RAS by co-mutation of codons 19 and 20 is transforming
por: Naguib, Adam, et al.
Publicado: (2011) -
Mutations of K-ras oncogene in human adrenal tumours in Taiwan.
por: Lin, S. R., et al.
Publicado: (1998) -
Blocking K-Ras Interaction With the Plasma Membrane Is a Tractable Therapeutic Approach to Inhibit Oncogenic K-Ras Activity
por: Henkels, Karen M., et al.
Publicado: (2021)