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Fangchinoline induces G0/G1 arrest by modulating the expression of CDKN1A and CCND2 in K562 human chronic myelogenous leukemia cells

Chronic myeloid leukemia (CML) is a hematopoietic stem cell disease caused by the oncoprotein BCR-ABL, which exhibits a constitutive tyrosine kinase activity. Imatinib mesylate (IM), an inhibitor of the tyrosine kinase activity of BCR-ABL, has been used as a first-line therapy for CML. However, IM i...

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Detalles Bibliográficos
Autores principales:	WANG, YUPING, CHEN, JIE, WANG, LIN, HUANG, YUJI, LENG, YE, WANG, GUIYING
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2013
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627453/ https://www.ncbi.nlm.nih.gov/pubmed/23596478 http://dx.doi.org/10.3892/etm.2013.924

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