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Expanding probe repertoire and improving reproducibility in human genomic hybridization

Diagnostic DNA hybridization relies on probes composed of single copy (sc) genomic sequences. Sc sequences in probe design ensure high specificity and avoid cross-hybridization to other regions of the genome, which could lead to ambiguous results that are difficult to interpret. We examine how the d...

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Detalles Bibliográficos
Autores principales: Dorman, Stephanie N., Shirley, Ben C., Knoll, Joan H. M., Rogan, Peter K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627568/
https://www.ncbi.nlm.nih.gov/pubmed/23376933
http://dx.doi.org/10.1093/nar/gkt048