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Site- and strand-specific nicking of DNA by fusion proteins derived from MutH and I-SceI or TALE repeats
Targeted genome engineering requires nucleases that introduce a highly specific double-strand break in the genome that is either processed by homology-directed repair in the presence of a homologous repair template or by non-homologous end-joining (NHEJ) that usually results in insertions or deletio...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627573/ https://www.ncbi.nlm.nih.gov/pubmed/23408850 http://dx.doi.org/10.1093/nar/gkt080 |