The structural basis of actinomycin D–binding induces nucleotide flipping out, a sharp bend and a left-handed twist in CGG triplet repeats

Mostrar otras versiones (1)

The potent anticancer drug actinomycin D (ActD) functions by intercalating into DNA at GpC sites, thereby interrupting essential biological processes including replication and transcription. Certain neurological diseases are correlated with the expansion of (CGG)(n) trinucleotide sequences, which co...

Descripción completa

Detalles Bibliográficos
Autores principales: Lo, Yu-Sheng, Tseng, Wen-Hsuan, Chuang, Chien-Ying, Hou, Ming-Hon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627577/
https://www.ncbi.nlm.nih.gov/pubmed/23408860
http://dx.doi.org/10.1093/nar/gkt084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627577/
https://www.ncbi.nlm.nih.gov/pubmed/23408860
http://dx.doi.org/10.1093/nar/gkt084

Ejemplares similares