DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

Breast cancer genomes have revealed a novel form of mutation showers (kataegis) in which multiple same-strand substitutions at C:G pairs spaced one to several hundred nucleotides apart are clustered over kilobase-sized regions, often associated with sites of DNA rearrangement. We show kataegis can r...

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Detalles Bibliográficos
Autores principales: Taylor, Benjamin JM, Nik-Zainal, Serena, Wu, Yee Ling, Stebbings, Lucy A, Raine, Keiran, Campbell, Peter J, Rada, Cristina, Stratton, Michael R, Neuberger, Michael S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Genes and Chromosomes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628087/
https://www.ncbi.nlm.nih.gov/pubmed/23599896
http://dx.doi.org/10.7554/eLife.00534

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628087/
https://www.ncbi.nlm.nih.gov/pubmed/23599896
http://dx.doi.org/10.7554/eLife.00534

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