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Vascular-derived TGF-β increases in the stem cell niche and perturbs neurogenesis during aging and following irradiation in the adult mouse brain
Neurogenesis decreases during aging and following cranial radiotherapy, causing a progressive cognitive decline that is currently untreatable. However, functional neural stem cells remained present in the subventricular zone of high dose-irradiated and aged mouse brains. We therefore investigated wh...
Autores principales: | Pineda, Jose R, Daynac, Mathieu, Chicheportiche, Alexandra, Cebrian-Silla, Arantxa, Sii Felice, Karine, Garcia-Verdugo, Jose Manuel, Boussin, François D, Mouthon, Marc-André |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
WILEY-VCH Verlag
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628106/ https://www.ncbi.nlm.nih.gov/pubmed/23526803 http://dx.doi.org/10.1002/emmm.201202197 |
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