Mechanism for priming DNA synthesis by yeast DNA Polymerase α

The DNA Polymerase α (Pol α)/primase complex initiates DNA synthesis in eukaryotic replication. In the complex, Pol α and primase cooperate in the production of RNA-DNA oligonucleotides that prime synthesis of new DNA. Here we report crystal structures of the catalytic core of yeast Pol α in unligan...

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Detalles Bibliográficos
Autores principales: Perera, Rajika L, Torella, Rubben, Klinge, Sebastian, Kilkenny, Mairi L, Maman, Joseph D, Pellegrini, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628110/
https://www.ncbi.nlm.nih.gov/pubmed/23599895
http://dx.doi.org/10.7554/eLife.00482

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628110/
https://www.ncbi.nlm.nih.gov/pubmed/23599895
http://dx.doi.org/10.7554/eLife.00482

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