Radiation-induced senescence in securin-deficient cancer cells promotes cell invasion involving the IL-6/STAT3 and PDGF-BB/PDGFR pathways

Securin overexpression correlates with poor prognosis in various tumours. We have previously shown that securin depletion promotes radiation-induced senescence and enhances radiosensitivity in human cancer cells. However, the underlying molecular mechanisms and the paracrine effects remain unknown....

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Detalles Bibliográficos
Autores principales: Yu, Yi-Chu, Yang, Pei-Ming, Chuah, Qiu-Yu, Huang, Yao-Huei, Peng, Chih-Wen, Lee, Yi-Jang, Chiu, Shu-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628221/
https://www.ncbi.nlm.nih.gov/pubmed/23591770
http://dx.doi.org/10.1038/srep01675

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628221/
https://www.ncbi.nlm.nih.gov/pubmed/23591770
http://dx.doi.org/10.1038/srep01675

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