Cargando…

Radiation-induced senescence in securin-deficient cancer cells promotes cell invasion involving the IL-6/STAT3 and PDGF-BB/PDGFR pathways

Securin overexpression correlates with poor prognosis in various tumours. We have previously shown that securin depletion promotes radiation-induced senescence and enhances radiosensitivity in human cancer cells. However, the underlying molecular mechanisms and the paracrine effects remain unknown....

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Yi-Chu, Yang, Pei-Ming, Chuah, Qiu-Yu, Huang, Yao-Huei, Peng, Chih-Wen, Lee, Yi-Jang, Chiu, Shu-Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628221/ https://www.ncbi.nlm.nih.gov/pubmed/23591770 http://dx.doi.org/10.1038/srep01675

Ejemplares similares

PDGFR in PDGF-BB/PDGFR Signaling Pathway Does Orchestrates Osteogenesis in a Temporal Manner
por: Wang, Fangqian, et al.
Publicado: (2023)

A fibronectin peptide redirects PDGF-BB/PDGFR complexes to macropinocytosis-like internalization and augments PDGF-BB survival signals
por: Zhu, Jia, et al.
Publicado: (2013)

Targeting the PDGF-B/PDGFR-β Interface with Destruxin A5 to Selectively Block PDGF-BB/PDGFR-ββ Signaling and Attenuate Liver Fibrosis
por: Wang, Xingqi, et al.
Publicado: (2016)

Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFRβ and affect PDGF-BB-induced STAT3 signalling
por: Sarri, Niki, et al.
Publicado: (2022)

Comprehensive Dissection of PDGF-PDGFR Signaling Pathways in PDGFR Genetically Defined Cells
por: Wu, Erxi, et al.
Publicado: (2008)

Specific targeting of PDGFRβ in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression
por: Tsioumpekou, Maria, et al.
Publicado: (2020)

Tensile force-induced PDGF-BB/PDGFRβ signals in periodontal ligament fibroblasts activate JAK2/STAT3 for orthodontic tooth movement
por: Jin, Yuqin, et al.
Publicado: (2020)

Imatinib inhibits pericyte-fibroblast transition and inflammation and promotes axon regeneration by blocking the PDGF-BB/PDGFRβ pathway in spinal cord injury
por: Yao, Fei, et al.
Publicado: (2022)

Endothelial PDGF-BB/PDGFR-β signaling promotes osteoarthritis by enhancing angiogenesis-dependent abnormal subchondral bone formation
por: Cui, Zhuang, et al.
Publicado: (2022)

Endothelial progenitor cells promote viability and nerve regenerative ability of mesenchymal stem cells through PDGF-BB/PDGFR-β signaling
por: Fang, Jiafeng, et al.
Publicado: (2020)

Specific targeting of PDGFRβ in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression: Erratum
por: Tsioumpekou, Maria, et al.
Publicado: (2020)

Characterisation of PDGF-BB:PDGFRβ signalling pathways in human brain pericytes: evidence of disruption in Alzheimer’s disease
por: Smyth, Leon C. D., et al.
Publicado: (2022)

Elevated PDGF‐BB from Bone Impairs Hippocampal Vasculature by Inducing PDGFRβ Shedding from Pericytes
por: Liu, Guanqiao, et al.
Publicado: (2023)

PDGF-AA and PDGF-BB biosynthesis: proprotein processing in the Golgi complex and lysosomal degradation of PDGF-BB retained intracellularly
Publicado: (1992)

PDGF-D−PDGFRβ signaling enhances IL-15–mediated human natural killer cell survival
por: Ma, Shoubao, et al.
Publicado: (2022)

PDGF/PDGFR effects in osteosarcoma and the “add-on” strategy
por: Xu, Jie, et al.
Publicado: (2018)

PDGF-BB signaling via PDGFR-β regulates the maturation of blood vessels generated upon vasculogenic differentiation of dental pulp stem cells
por: Zhang, Zhaocheng, et al.
Publicado: (2022)

Effect on Osteogenic Differentiation of Genetically Modified IL4 or PDGF-BB Over-Expressing and IL4-PDGF-BB Co-Over-Expressing Bone Marrow-Derived Mesenchymal Stromal Cells In Vitro
por: Tsubosaka, Masanori, et al.
Publicado: (2021)

Endothelial Cells Promote Migration of Mesenchymal Stem Cells via PDGF-BB/PDGFRβ-Src-Akt in the Context of Inflammatory Microenvironment upon Bone Defect
por: He, Sihao, et al.
Publicado: (2022)

Effects of ginsenoside Rb1 on second-degree burn wound healing and FGF-2/PDGF-BB/PDGFR-β pathway modulation
por: Zhang, Li, et al.
Publicado: (2021)

Low plasma PDGF-BB levels are associated with estradiol in postmenopausal osteoporosis: PDGF-BB mediated by estradiol in women
por: Tang, Lanhua, et al.
Publicado: (2017)

Inhibitory Effects of Resveratrol on PDGF-BB-Induced Retinal Pigment Epithelial Cell Migration via PDGFRβ, PI3K/Akt and MAPK pathways
por: Chan, Chi-Ming, et al.
Publicado: (2013)

Goniolactone C, a Styryl Lactone Derivative, Inhibits PDGF-BB-Induced Vascular Smooth Muscle Cell Migration and Proliferation via PDGFR/ERK Signaling
por: Sun, Lan, et al.
Publicado: (2014)

Securin correct separation
por: LeBrasseur, Nicole
Publicado: (2002)

VEGF-A/VEGFR-2 and FGF-2/FGFR-1 but not PDGF-BB/PDGFR-β play important roles in promoting immature and inflammatory intraplaque angiogenesis
por: Mao, Yang, et al.
Publicado: (2018)

miR-34c inhibits PDGF-BB-induced HAVSMCs phenotypic transformation and proliferation via PDGFR-β/SIRT1 pathway
por: Wan, Wei-feng, et al.
Publicado: (2021)

PDGF/PDGFR: A Possible Molecular Target in Scleroderma Fibrosis
por: Paolini, Chiara, et al.
Publicado: (2022)

Antiproliferative effects of imatinib mesylate on ZR-75-1 and MDA-MB-231 cell lines via PDGFR-β, PDGF-BB, c-Kit and SCF expression
por: Kadivar, Ali, et al.
Publicado: (2019)

Securin Is Not Required for Chromosomal Stability in Human Cells
por: Pfleghaar, Katrin, et al.
Publicado: (2005)

Platelet-Derived Growth Factor (PDGF)/PDGF Receptors (PDGFR) Axis as Target for Antitumor and Antiangiogenic Therapy
por: Raica, Marius, et al.
Publicado: (2010)

Osteoclasts Control Osteoblast Chemotaxis via PDGF-BB/PDGF Receptor Beta Signaling
por: Sanchez-Fernandez, Maria Arantzazu, et al.
Publicado: (2008)

PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF beta-receptors
Publicado: (1994)

Development of renal renin-expressing cells does not involve PDGF-B-PDGFR-β signaling
por: Neubauer, Bjoern, et al.
Publicado: (2013)

Yohimbine, an α2-Adrenoceptor Antagonist, Suppresses PDGF-BB-Stimulated Vascular Smooth Muscle Cell Proliferation by Downregulating the PLCγ1 Signaling Pathway
por: Chiu, Chih-Wei, et al.
Publicado: (2022)

STIM1 Knockout Enhances PDGF-Mediated Ca(2+) Signaling through Upregulation of the PDGFR–PLCγ–STIM2 Cascade
por: Huang, Tzu-Yu, et al.
Publicado: (2018)

Dual roles of endothelial FGF-2–FGFR1–PDGF-BB and perivascular FGF-2–FGFR2–PDGFRβ signaling pathways in tumor vascular remodeling
por: Hosaka, Kayoko, et al.
Publicado: (2018)

An Insecure Role for Securin in Chromosome Segregation
Publicado: (2005)

Global profile of genes regulated by securin
por: Kakar, Sham S, et al.
Publicado: (2008)

Molecular Characterization of PDGFR-α/PDGF-A and c-KIT/SCF in Gliosarcomas
por: Reis, Rui M., et al.
Publicado: (2005)

Regulation of T cell proliferation by JMJD6 and PDGF-BB during chronic hepatitis B infection
por: Chen, Cai-Feng, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_ibcjgf1nvraaqv0s5a1nlod8hr