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Cycling of the signaling protein phospholipase D through cilia requires the BBSome only for the export phase

The BBSome is a complex of seven proteins, including BBS4, that is cycled through cilia by intraflagellar transport (IFT). Previous work has shown that the membrane-associated signaling protein phospholipase D (PLD) accumulates abnormally in cilia of Chlamydomonas reinhardtii bbs mutants. Here we sh...

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Detalles Bibliográficos
Autores principales: Lechtreck, Karl F., Brown, Jason M., Sampaio, Julio L., Craft, Julie M., Shevchenko, Andrej, Evans, James E., Witman, George B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628507/
https://www.ncbi.nlm.nih.gov/pubmed/23589493
http://dx.doi.org/10.1083/jcb.201207139