Deletion of Aldose Reductase from Mice Inhibits Diabetes-Induced Retinal Capillary Degeneration and Superoxide Generation

PURPOSE: Pharmacologic inhibition of aldose reductase (AR) previously has been studied with respect to diabetic retinopathy with mixed results. Since drugs can have off-target effects, we studied the effects of AR deletion on the development and molecular abnormalities that contribute to diabetic re...

Descripción completa

Detalles Bibliográficos
Autores principales: Tang, Jie, Du, Yunpeng, Petrash, J. Mark, Sheibani, Nader, Kern, Timothy S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628579/
https://www.ncbi.nlm.nih.gov/pubmed/23614016
http://dx.doi.org/10.1371/journal.pone.0062081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628579/
https://www.ncbi.nlm.nih.gov/pubmed/23614016
http://dx.doi.org/10.1371/journal.pone.0062081

Ejemplares similares