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Deletion of Aldose Reductase from Mice Inhibits Diabetes-Induced Retinal Capillary Degeneration and Superoxide Generation

PURPOSE: Pharmacologic inhibition of aldose reductase (AR) previously has been studied with respect to diabetic retinopathy with mixed results. Since drugs can have off-target effects, we studied the effects of AR deletion on the development and molecular abnormalities that contribute to diabetic re...

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Detalles Bibliográficos
Autores principales:	Tang, Jie, Du, Yunpeng, Petrash, J. Mark, Sheibani, Nader, Kern, Timothy S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628579/ https://www.ncbi.nlm.nih.gov/pubmed/23614016 http://dx.doi.org/10.1371/journal.pone.0062081

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