ERK2 Suppresses Self-Renewal Capacity of Embryonic Stem Cells, but Is Not Required for Multi-Lineage Commitment

Activation of the FGF-ERK pathway is necessary for naïve mouse embryonic stem (ES) cells to exit self-renewal and commit to early differentiated lineages. Here we show that genetic ablation of Erk2, the predominant ERK isozyme expressed in ES cells, results in hyper-phosphorylation of ERK1, but an o...

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Detalles Bibliográficos
Autores principales: Hamilton, William B., Kaji, Keisuke, Kunath, Tilo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628700/
https://www.ncbi.nlm.nih.gov/pubmed/23613754
http://dx.doi.org/10.1371/journal.pone.0060907

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628700/
https://www.ncbi.nlm.nih.gov/pubmed/23613754
http://dx.doi.org/10.1371/journal.pone.0060907

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