Acidosis Activation of the Proton-Sensing GPR4 Receptor Stimulates Vascular Endothelial Cell Inflammatory Responses Revealed by Transcriptome Analysis

Acidic tissue microenvironment commonly exists in inflammatory diseases, tumors, ischemic organs, sickle cell disease, and many other pathological conditions due to hypoxia, glycolytic cell metabolism and deficient blood perfusion. However, the molecular mechanisms by which cells sense and respond t...

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Detalles Bibliográficos
Autores principales: Dong, Lixue, Li, Zhigang, Leffler, Nancy R., Asch, Adam S., Chi, Jen-Tsan, Yang, Li V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628782/
https://www.ncbi.nlm.nih.gov/pubmed/23613998
http://dx.doi.org/10.1371/journal.pone.0061991

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628782/
https://www.ncbi.nlm.nih.gov/pubmed/23613998
http://dx.doi.org/10.1371/journal.pone.0061991

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