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Quantification of N-acetylcysteamine activated methylmalonate incorporation into polyketide biosynthesis

Polyketides are biosynthesized through consecutive decarboxylative Claisen condensations between a carboxylic acid and differently substituted malonic acid thioesters, both tethered to the giant polyketide synthase enzymes. Individual malonic acid derivatives are typically required to be activated a...

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Detalles Bibliográficos
Autores principales: Klopries, Stephan, Sundermann, Uschi, Schulz, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628877/
https://www.ncbi.nlm.nih.gov/pubmed/23616811
http://dx.doi.org/10.3762/bjoc.9.75