In Vivo Analysis of Aicda Gene Regulation: A Critical Balance between Upstream Enhancers and Intronic Silencers Governs Appropriate Expression

The Aicda gene encodes activation-induced cytidine deaminase (AID). Aicda is strongly transcribed in activated B cells to diversify immunoglobulin genes, but expressed at low levels in various other cells in response to physiological or pathological stimuli. AID’s mutagenic nature has been shown to...

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Detalles Bibliográficos
Autores principales: Huong, Le Thi, Kobayashi, Maki, Nakata, Mikiyo, Shioi, Go, Miyachi, Hitoshi, Honjo, Tasuku, Nagaoka, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628980/
https://www.ncbi.nlm.nih.gov/pubmed/23613851
http://dx.doi.org/10.1371/journal.pone.0061433

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628980/
https://www.ncbi.nlm.nih.gov/pubmed/23613851
http://dx.doi.org/10.1371/journal.pone.0061433

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