Functional and Structural Analysis of C-Terminal BRCA1 Missense Variants

Germline inactivating mutations in BRCA1 and BRCA2 genes are responsible for Hereditary Breast and Ovarian Cancer Syndrome (HBOCS). Genetic testing of these genes is available, although approximately 15% of tests identify variants of uncertain significance (VUS). Classification of these variants int...

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Detalles Bibliográficos
Autores principales: Quiles, Francisco, Fernández-Rodríguez, Juana, Mosca, Roberto, Feliubadaló, Lídia, Tornero, Eva, Brunet, Joan, Blanco, Ignacio, Capellá, Gabriel, Pujana, Miquel Àngel, Aloy, Patrick, Monteiro, Alvaro, Lázaro, Conxi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629201/
https://www.ncbi.nlm.nih.gov/pubmed/23613828
http://dx.doi.org/10.1371/journal.pone.0061302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629201/
https://www.ncbi.nlm.nih.gov/pubmed/23613828
http://dx.doi.org/10.1371/journal.pone.0061302

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