Permeability Enhancers Dramatically Increase Zanamivir Absolute Bioavailability in Rats: Implications for an Orally Bioavailable Influenza Treatment

We have demonstrated that simple formulations composed of the parent drug in combination with generally regarded as safe (GRAS) permeability enhancers are capable of dramatically increasing the absolute bioavailability of zanamivir. This has the advantage of not requiring modification of the drug st...

Descripción completa

Detalles Bibliográficos
Autores principales: Holmes, Eric H., Devalapally, Harikrishna, Li, Libin, Perdue, Michael L., Ostrander, Gary K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629230/
https://www.ncbi.nlm.nih.gov/pubmed/23613954
http://dx.doi.org/10.1371/journal.pone.0061853

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629230/
https://www.ncbi.nlm.nih.gov/pubmed/23613954
http://dx.doi.org/10.1371/journal.pone.0061853

Ejemplares similares