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New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2

Talins are adaptor proteins that connect the integrin family of cell adhesion receptors to cytoskeletal actin. Vertebrates express two closely related talins encoded by separate genes, and while it is well established that talin1 plays a key role in cell adhesion and spreading, little is known about...

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Detalles Bibliográficos
Autores principales: Praekelt, Uta, Kopp, Petra M., Rehm, Kerstin, Linder, Stefan, Bate, Neil, Patel, Bipin, Debrand, Emmanuel, Manso, Ana Maria, Ross, Robert S., Conti, Franceso, Zhang, Ming-Zhi, Harris, Raymond C., Zent, Roy, Critchley, David R., Monkley, Susan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629562/
https://www.ncbi.nlm.nih.gov/pubmed/22306379
http://dx.doi.org/10.1016/j.ejcb.2011.12.003